PI3K/Akt/mTOR Signaling Pathway Inhibitors

The PI3K/Akt/mTOR pathway plays an important role in apoptosis. Activated PI3K generates phosphatidylinositol-3,4,5-triphosphate, which recruits PDK1 and Akt serine/threonine kinase at the plasma membrane. This results in the activation of Akt. Akt activates multiple downstream targets including the mTOR pathway.

Various receptor tyrosine kinases (RTKs) - HER2, EGFR, IGF-1R and VEGFR - activate the growth and survival mechanisms of cells by mobilizing the intracellular PI3K signaling pathway. The carcinogenic role of the PI3K pathway was initially observed when PI3K mutation-induced abnormal cellular signaling was found to be associated with malignant proliferation and growth in many types of cancer.

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Cat. No.DescriptionProduct groups

Akt activators

S7863SC79 [CAS no: 305834-79-1]Chemicals

Akt inhibitors

S2670A-674563 (CAS no: 552325-73-2)Chemicals
S7521Afuresertib (GSK2110183) [CAS no: 1047644-62-1]Chemicals
S7776Akti-1/2 [CAS no: 612847-09-3]Chemicals
S7563AT13148 [CAS no: 1056901-62-2]Chemicals
S1558AT7867 (CAS no: 857531-00-1)Chemicals
S8019AZD5363 (CAS no: 1143532-39-1)Chemicals
S2635CCT128930 (CAS no: 885499-61-6)Chemicals
S2808GDC-0068 (CAS no: 1001264-89-6)Chemicals
S1113GSK690693 (CAS no: 937174-76-0)Chemicals
S2310Honokiol (CAS no: 35354-74-6)Chemicals
S3056Miltefosine (CAS no: 58066-85-6)Chemicals
S1078MK-2206 2HCl (CAS no: 1032350-13-2)Chemicals
S1037Perifosine (KRX-0401) (CAS no: 157716-52-4)Chemicals
S2743PF-04691502 (CAS no: 1013101-36-4)Chemicals
S1556PHT-427 (CAS no: 1191951-57-1)Chemicals
S7127TIC10 (CAS no: 41276-02-2)Chemicals
S7963TIC10 [CAS no: 1616632-77-9]Chemicals
S1117Triciribine (CAS no: 35943-35-2)Chemicals

AMPK activators

S2697A-769662 (CAS no: 844499-71-4)Chemicals
S1802Acadesine (CAS no: 2627-69-2)Chemicals
S7898GSK621 [CAS no: 1346607-05-3]Chemicals
S2542Phenformin HCl (CAS no: 834-28-6)Chemicals

AMPK inhibitors

S7840Dorsomorphin (Compound C) [CAS no: 866405-64-3]Chemicals
S7306Dorsomorphin 2HCl (CAS no: 1219168-18-9)Chemicals
S7318HTH-01-015 [CAS no: 1613724-42-7]Chemicals
S7317WZ4003 (CAS no: 1214265-58-3)Chemicals

ATM/ATR activators

S4157Chloroquine Phosphate (CAS no: 50-63-5)Chemicals

ATM/ATR inhibitors

S7050AZ20 (CAS no: 1233339-22-4)Chemicals
S7693AZD6738 [CAS no: 1352226-88-0]Chemicals
S1009BEZ235 (NVP-BEZ235, Dactolisib) (CAS no: 915019-65-7)Chemicals
S7136CGK 733 (CAS no: 905973-89-9)Chemicals
S2245CP-466722 (CAS no: 1080622-86-1)Chemicals
S8050ETP-46464 (CAS no: 1345675-02-6)Chemicals
S1092KU-55933 (ATM Kinase Inhibitor) (CAS no: 587871-26-9)Chemicals
S1570KU-60019 (CAS no: 925701-49-1)Chemicals
S3600Schisandrin B (Sch B) (CAS no: 61281-37-6)Chemicals
S2817Torin 2 (CAS no: 1223001-51-1)Chemicals
S8007VE-821 (CAS no: 1232410-49-9)Chemicals
S7102VE-822 (CAS no: 1232416-25-9)Chemicals
S2758Wortmannin (CAS no: 19545-26-7)Chemicals

DNA-PK inhibitors

S8045KU-0060648 (CAS no: 881375-00-4)Chemicals
S2893NU7026 (CAS no: 154447-35-5)Chemicals
S2638NU7441 (KU-57788) (CAS no: 503468-95-9)Chemicals
S1038PI-103 (CAS no: 371935-74-9)Chemicals
S1205PIK-75 (CAS no: 372196-77-5)Chemicals
S2622PP121 (CAS no: 1092788-83-4)Chemicals

GSK-3 inhibitors

S71931-Azakenpaullone (CAS no: 676596-65-9)Chemicals
S7435AR-A014418 (CAS no: 487021-52-3)Chemicals
S7145AZD1080 (CAS no: 612487-72-6)Chemicals
S7253AZD2858 (CAS no: 486424-20-8)Chemicals
S7722Bikinin [CAS no: 188011-69-0]Chemicals
S7198BIO (CAS no: 667463-62-9)Chemicals
S7915BIO-acetoxime [CAS no: 667463-85-6]Chemicals
S2745CHIR-98014 (CAS no: 252935-94-7)Chemicals
S1263CHIR-99021 (CT99021) [CAS no: 252917-06-9]Chemicals
S2924CHIR-99021 (CT99021) HCl (CAS no: 252917-06-9)Chemicals
S7566IM-12 [CAS no: 1129669-05-1]Chemicals
S2386Indirubin (CAS no: 479-41-4)Chemicals
S7063LY2090314 (CAS no: 603288-22-8)Chemicals
S1075SB216763 (CAS no: 280744-09-4)Chemicals
S2729SB415286 (CAS no: 264218-23-7)Chemicals
S2926TDZD-8 [CAS no: 327036-89-5]Chemicals
S2823Tideglusib (CAS no: 865854-05-3)Chemicals
S1590TWS119 (CAS no: 601514-19-6)Chemicals

mTOR activators

S7811MHY1485 [CAS no: 326914-06-1]Chemicals

mTOR inhibitors

S2783AZD2014 (CAS no: 1009298-59-2)Chemicals
S1555AZD8055 (CAS no: 1009298-09-2)Chemicals
S1009BEZ235 (NVP-BEZ235, Dactolisib) (CAS no: 915019-65-7)Chemicals
S2749BGT226 (NVP-BGT226) (CAS no: 1245537-68-1)Chemicals
S2699CH5132799 (CAS no: 1007207-67-1)Chemicals
S2406Chrysophanic Acid (CAS no: 481-74-3)Chemicals
S8050ETP-46464 (CAS no: 1345675-02-6)Chemicals
S1120Everolimus (RAD001) (CAS no: 159351-69-6)Chemicals
S8040GDC-0349 (CAS no: 1207360-89-1)Chemicals
S2696GDC-0980 (RG7422) (CAS no: 1032754-93-0)Chemicals
S1360GSK1059615 (CAS no: 958852-01-2)Chemicals
S2658GSK2126458 (GSK458) (CAS no: 1086062-66-9)Chemicals
S2811INK 128 (MLN0128) (CAS no: 1224844-38-5)Chemicals
S1226KU-0063794 (CAS no: 938440-64-3)Chemicals
S2624OSI-027 (CAS no: 936890-98-1)Chemicals
S2238Palomid 529 (P529) (CAS no: 914913-88-5)Chemicals
S2743PF-04691502 (CAS no: 1013101-36-4)Chemicals
S2628PF-05212384 (PKI-587) (CAS no: 1197160-78-3)Chemicals
S1038PI-103 (CAS no: 371935-74-9)Chemicals
S2622PP121 (CAS no: 1092788-83-4)Chemicals
S2218PP242 (CAS no: 1092351-67-1)Chemicals
S1039Rapamycin (Sirolimus) (CAS no: 53123-88-9)Chemicals
S1022Ridaforolimus (Deforolimus, MK-8669) (CAS no: 572924-54-0)Chemicals
S1523SAR245409 (XL765) (CAS no: 1349796-36-6)Chemicals
S5003Tacrolimus (FK506) (CAS no: 104987-11-3)Chemicals
S1044Temsirolimus (CCI-779, NSC 683864) (CAS no: 162635-04-3)Chemicals
S2827Torin 1 (CAS no: 1222998-36-8)Chemicals
S2817Torin 2 (CAS no: 1223001-51-1)Chemicals
S7646Voxtalisib (XL765, SAR245409) [CAS no: 934493-76-2]Chemicals
S2689WAY-600 (CAS no: 1062159-35-6)Chemicals
S2661WYE-125132 (WYE-132) (CAS no: 1144068-46-1)Chemicals
S1266WYE-354 (CAS no: 1062169-56-5)Chemicals
S2668WYE-687 (CAS no: 1062161-90-3)Chemicals
S7035XL388 (CAS no: 1251156-08-7)Chemicals
S7091Zotarolimus(ABT-578) [CAS no: 221877-54-9]Chemicals

PDK-1 inhibitors

S1274BX-795 (CAS no: 702675-74-9)Chemicals
S1275BX-912 (CAS no: 702674-56-4)Chemicals
S7087GSK2334470 (CAS no: 1227911-45-6)Chemicals
S1106OSU-03012 (AR-12) (CAS no: 742112-33-0)Chemicals
S1556PHT-427 (CAS no: 1191951-57-1)Chemicals

PI3K inhibitors

S27673-Methyladenine (CAS no: 5142-23-4)Chemicals
S2636A66 (CAS no: 1166227-08-2)Chemicals
S7813AMG319 [CAS no: 1608125-21-8]Chemicals
S2671AS-252424 (CAS no: 900515-16-4)Chemicals
S2681AS-604850 (CAS no: 648449-76-7)Chemicals
S1410AS-605240 (CAS no: 648450-29-7)Chemicals
S1462AZD6482 (CAS no: 1173900-33-8)Chemicals
S7694AZD8186 [CAS no: 1627494-13-6]Chemicals
S2802BAY 80-6946 (Copanlisib) (CAS no: 1032568-63-0)Chemicals
S1009BEZ235 (NVP-BEZ235, Dactolisib) (CAS no: 915019-65-7)Chemicals
S2749BGT226 (NVP-BGT226) (CAS no: 1245537-68-1)Chemicals
S2247BKM120 (NVP-BKM120, Buparlisib) (CAS no: 944396-07-0)Chemicals
S2814BYL719 (CAS no: 1217486-61-7)Chemicals
S2226CAL-101 (Idelalisib, GS-1101) (CAS no: 870281-82-6)Chemicals
S2682CAY10505 (CAS no: 1218777-13-9)Chemicals
S2699CH5132799 (CAS no: 1007207-67-1)Chemicals
S2759CUDC-907 (CAS no: 1339928-25-4)Chemicals
S7018CZC24832 (CAS no: 1159824-67-5)Chemicals
S7103GDC-0032 (CAS no: 1282512-48-4)Chemicals
S1065GDC-0941 (CAS no: 957054-30-7)Chemicals
S2696GDC-0980 (RG7422) (CAS no: 1032754-93-0)Chemicals
S7798GNE-317 [CAS no: 1394076-92-6]Chemicals
S1360GSK1059615 (CAS no: 958852-01-2)Chemicals
S2658GSK2126458 (GSK458) (CAS no: 1086062-66-9)Chemicals
S8002GSK2636771 (CAS no: 1372540-25-4)Chemicals
S7356HS-173 [CAS no: 1276110-06-5]Chemicals
S1268IC-87114 (CAS no: 371242-69-2)Chemicals
S7028IPI-145 (INK1197) (CAS no: 1201438-56-3)Chemicals
S1105LY294002 (CAS no: 154447-36-6)Chemicals
S2638NU7441 (KU-57788) (CAS no: 503468-95-9)Chemicals
S2743PF-04691502 (CAS no: 1013101-36-4)Chemicals
S2628PF-05212384 (PKI-587) (CAS no: 1197160-78-3)Chemicals
S7675PF-4989216 [CAS no: 1276553-09-3]Chemicals
S1038PI-103 (CAS no: 371935-74-9)Chemicals
S7623PI-3065 [CAS no: 955977-50-1]Chemicals
S2207PIK-293 (CAS no: 900185-01-5)Chemicals
S2227PIK-294 (CAS no: 900185-02-6)Chemicals
S1205PIK-75 (CAS no: 372196-77-5)Chemicals
S1187PIK-90 (CAS no: 677338-12-4)Chemicals
S1489PIK-93 (CAS no: 593960-11-3)Chemicals
S7645Pilaralisib (XL147) [CAS no: 934526-89-3]Chemicals
S2739PKI-402 (CAS no: 1173204-81-3)Chemicals
S2391Quercetin (CAS no: 117-39-5)Chemicals
S1523SAR245409 (XL765) (CAS no: 1349796-36-6)Chemicals
S1352TG100-115 (CAS no: 677297-51-7)Chemicals
S2870TG100713 (CAS no: 925705-73-3)Chemicals
S1169TGX-221 (CAS no: 663619-89-4)Chemicals
S7646Voxtalisib (XL765, SAR245409) [CAS no: 934493-76-2]Chemicals
S7016VS-5584 (SB2343) (CAS no: 1246560-33-7)Chemicals
S2758Wortmannin (CAS no: 19545-26-7)Chemicals
S1118XL147 (CAS no: 956958-53-5)Chemicals
S1219YM201636 (CAS no: 371942-69-7)Chemicals
S1072ZSTK474 (CAS no: 475110-96-4)Chemicals

S6 Kinase inhibitors

S7563AT13148 [CAS no: 1056901-62-2]Chemicals
S1558AT7867 (CAS no: 857531-00-1)Chemicals
S2843BI-D1870 (CAS no: 501437-28-1)Chemicals
S1582H 89 2HCl (CAS no: 130964-39-5)Chemicals
S7871LJI308 [CAS no: 1627709-94-7]Chemicals
S7698LY2584702 [CAS no: 1082949-67-4]Chemicals
S7704LY2584702 Tosylate [CAS no: 1082949-68-5]Chemicals
S2163PF-4708671 (CAS no: 1255517-76-0)Chemicals



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Brands: Selleck Chemicals
Product groups: Chemicals​