PI3K-Akt-mTOR Pathway Antibodies

Akt, also known as protein kinase B (PKB) is a serine/threonine kinase that plays an important role in oncogenesis and the cellular processes of metabolism, apoptosis and autophagy. AKT is activated through phosphorylation (at either T308 or S473) by an activating kinase after being recruited to the plasma membrane by PIP3. The availability of PIP3 at the plasma membrane is tightly regulated by the opposing processes of PI 3-Kinase (PI3K), which phosphorylates PIP2 to PIP3, and PTEN, which dephosphorylates PIP3 and abrogates AKT recruitment. Constitutive activation of PI3K or loss of PTEN function are both associated with oncogenic progression. The mammalian target of rapamycin (mTOR) has been identified as the critical downstream mediator of AKT’s oncogenic properties. Together with the proteins GbL, Raptor and PRAS40, mTOR forms the mTORC1 complex. This complex induces cell growth by stimulating protein synthesis, driving cell cycle progression and inhibiting autophagy. mTOR can also associate with different proteins to form a functionally distinct complex, the rapamycin-insensitive mTORC2. It has recently been discovered that mTORC2 directly phosphorylates and activates AKT, indicating that mTOR has a complicated role both upstream and downstream of AKT. GeneTex is proud to offer a complete line of antibodies for studying the various components of the PI3K-Akt-mTOR signaling pathway.



Targets
AKT AntibodyEzrin AntibodyPEA15 AntibodyPRR5 Antibody
AKT1 AntibodyFKHR AntibodyPI3K-AKT AntibodyPTEN Antibody
AKT2 AntibodyFOXO3A AntibodyPIK3C2A AntibodyPTP1B Antibody
AKT3 AntibodyFOXO4 AntibodyPIK3C3 AntibodyRaf1 Antibody
AKT-mTOR AntibodyGSK3A AntibodyPIK3CA AntibodyRaptor Antibody
AS160 AntibodyGSK3B AntibodyPIK3CB AntibodyRHEB Antibody
ASK1 AntibodyHamartin AntibodyPIK3CD AntibodyRICTOR Antibody
BAD AntibodyIKK alpha AntibodyPIK3CG AntibodyS6 Ribosomal Antibody
Chk1 AntibodyMDM2 AntibodyPIK3R1 AntibodySEK1 Antibody
CREB AntibodyMKK4 AntibodyPIK3R2 AntibodySIN1 Antibody
DEPDC6 AntibodymTOR AntibodyPIK3R4 AntibodyTSC1 Antibody
eIF4B AntibodyP110alpha AntibodyPIK3R5 AntibodyTSC2 Antibody
eNOS Antibodyp21Cip1 AntibodyPRAS40 AntibodyTuberin Antibody
Estrogen AntibodyPDCD4 AntibodyProtor1 AntibodyVPS34 Antibody

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Brands: GeneTex
Product groups: Antibodies