LentiBrite Histone H2B-GFP Lentiviral Biosensor

Catalog number: 17-10229
Brand: Merck
Packing: 1 Vials
Price: € 537.00
Expected delivery time: 7 days

Product specifications for - LentiBrite Histone H2B-GFP Lentiviral Biosensor

Product group: DNA / RNA / Vectors
Category: Plasmid / vector
  Research Use Only
UNSPSC: 41106600
Storage instructions: Storage and HandlingLentivirus is stable for at least 4 months from date of receipt when stored at -80-¦C. After first thaw, place immediately on ice and freeze in working aliquots at -80-¦C. Frozen aliquots may be stored for at least 2 months. Further freeze/thaws may result in decreased virus titer and transduction efficiency. IMPORTANT SAFETY NOTEReplication-defective lentiviral vectors, such as the 3rd Generation vector provided in this product, are not known to cause any diseas
Scientific information: 
Scientific info: Chromatin, the higher order structure of DNA and nucleosomes, constitutes the majority of the nucleus of the eukaryotic cell. Changes in chromatin structure are the essence of many essential nuclear processes, including transcription, mitosis, meiosis, and apoptosis. The nucleosome comprises an octomer of four core histone proteins (H2A, H2B, H3 and H4). Genetic fusions between histone H2B and fluorescent proteins have been widely used in live cells to visualize the dynamics of chromosomal architecture during various processes. In addition to its utility for studying normal mitosis, histone H2B-GFP has been utilized to define mechanisms for asymmetric inheritance of oncogenic double minute chromosomes. Monitoring histone H2B-GFP also permits continuous analysis of chromosomal degradation during apoptosis. Use of histone H2B-GFP has recently been extended to live animals and high-throughput siRNA screens. EMD Millipore’s LentiBrite Histone H2B-GFP lentiviral particles provide bright fluorescence and precise localization to enable live cell analysis of chromosomal dynamics in difficult-to-transfect cell types.
Additional information: 
Synonyms: 17-10229; Merck (Millipore)