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Boceprevir [394730-60-0]

Boceprevir [394730-60-0]

Research Use Only
AG-CR1-3735
AdipoGen Life Sciences
CAS Number394730-60-0
Product group Chemicals
Estimated Purity>98%
Molecular Weight519.7
Price on request
Packing Size
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Boceprevir [394730-60-0]
  • Delivery Days Customer
    10
  • CAS Number
    394730-60-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C27H45N5O5
  • Molecular Weight
    519.7
  • Scientific Description
    Chemical. CAS: 394730-60-0. Formula: C27H45N5O5. MW: 519.7. The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13microM). - The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13microM).
  • SMILES
    [H][C@]1(C2(C)C)[C@]2([H])CN(C([C@H](C(C)(C)C)NC(NC(C)(C)C)=O)=O)[C@]1([H])C(NC(CC3CCC3)C(C(N)=O)=O)=O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200