GTX70230 WB Image
GTX70230 WB Image
Rad51 antibody [14B4] - KO/KD, Orthogonal Validated
GTX70230
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityChicken, Human, Mouse, Rat
Overview
- SupplierGeneTex
- Product NameRad51 antibody [14B4] - KO/KD, Orthogonal Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID14B4
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
- ReactivityChicken, Human, Mouse, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization. Jeyasekharan AD et al., 2013 Oct, Nat Struct Mol BiolRead more
- A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice. Zhang H et al., 2016 Jan 5, Nat CommunRead more
- A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability. Tan SLW et al., 2017 Jun 1, CellRead more
- A marker of homologous recombination predicts pathologic complete response to neoadjuvant chemotherapy in primary breast cancer. Graeser M et al., 2010 Dec 15, Clin Cancer ResRead more
- A mitotic function for the high-mobility group protein HMG20b regulated by its interaction with the BRC repeats of the BRCA2 tumor suppressor. Lee M et al., 2011 Jul 28, OncogeneRead more
- A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity. Uringa EJ et al., 2015 Jan, DNA Repair (Amst)Read more
- A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks. Suzuki K et al., 2010 Jul, Nucleic Acids ResRead more
- A novel small molecule RAD51 inactivator overcomes imatinib-resistance in chronic myeloid leukaemia. Zhu J et al., 2013 Mar, EMBO Mol MedRead more
- A small ubiquitin binding domain inhibits ubiquitin-dependent protein recruitment to DNA repair foci. Helchowski CM et al., 2013 Dec 15, Cell CycleRead more
- A synthetic lethal screen identifies the Vitamin D receptor as a novel gemcitabine sensitizer in pancreatic cancer cells. Bhattacharjee V et al., 2014, Cell CycleRead more